Drug Name Reglan

Fenestrated endothelia are found in the capillaries of the gut and endocrine glands. In the central nervous system (brain and spinal cord), capillary endothelia lack pores and there is little transcytotic activity. In order to cross the blood-brain barrier, drugs must diffuse transcellularly, i.e., penetrate the luminal and basal membrane of endothelial cells.
Presumably, amantadine blocks a channel protein in the viral coat that permits influx of protons; thus, “uncoating” is prevented. Moreover, amantadine inhibits viral maturation. The drug is also used prophylactically and, if possible, must be taken before the outbreak of symptoms. It also is an antiparkinsonian.

 

Promethazine represents the transition to the neuroleptic phenothiazines. Unwanted effects of most H1-antihistamines are lassitude (impaired driving skills) and atropine- like reactions (e.g., dry mouth, constipation). At the usual therapeutic doses, astemizole, cetrizine, fexofenadine, and loratidine are practically devoid of sedative and anticholinergic effects.
Because this therapy fails to elevate mood but removes psychomotor inhibition (A), the danger of suicide increases. Tricyclic antidepressants (TCA; prototype: imipramine) have had the longest and most extensive therapeutic use; however, in the past decade, they have been increasingly superseded by the serotonin-selective reuptake inhibitors (SSRI; prototype: fluoxetine).