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When sweating is inhibited due to poisoning with anticholinergics (e. g. , atropine), cutaneous blood flow increases. If insufficient heat is dissipated through this route, overheating occurs (hyperthermia). Thyroid hyperfunction poses a particular challenge to the thermoregulatory system, because the excessive secretion of thyroid hormones causes metabolic heat production to increase.
The body responds by restricting heat loss (cutaneous vasoconstriction > chills) and by elevating heat production (shivering), in order to adjust to the new set point (fever). Antipyretics such as acetaminophen and ASA (p. 198) return the set point to its normal level (B2) and thus bring about a defervescence. Local anesthetics reversibly inhibit impulse generation and propagation in nerves. |
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