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By itself, the latter is enzymatically inactive; only after binding to a plasminogen molecule does the complex become effective in converting plasminogen to plasmin. Streptokinase is produced by streptococcal bacteria, which probably accounts for the frequent adverse reactions. Streptokinase antibodies may be present as a result of prior streptococcal infections.
Inhibition of the enzyme causes free NE concentrations to rise. Likewise, dopamine catabolism is impaired, making more of it available for NE synthesis. Consequently, the amount of NE stored in granular vesicles will increase, and with it the amount of amine released per nerve impulse. In the CNS, inhibition of MAO affects neuronal storage not only of NE but also of dopamine and serotonin.

 

The ability to chelate Ca2+ accounts for the propensity of tetracyclines to accumulate in growing teeth and bones. As a result, there occurs an irreversible yellowbrown discoloration of teeth and a reversible inhibition of bone growth. Because of these adverse effects, tetracycline should not be given after the second month of pregnancy and not prescribed to children aged 8 y and under.
Because of the need for constant intake at the same time of day, a lower success rate, and relatively frequent bleeding anomalies, these preparations are now rarely employed. “Morning-after” pill. This refers to administration of a high dose of estrogen and progestin, preferably within 12 to 24 h, but no later than 72 h after coitus.

 

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