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Locally applied (nasal drops) vasoconstricting ?- sympathomimetics decongest the nasal mucosa and dry up secretions, clearing the nasal passage. Long-term use may cause damage to nasal mucous membranes). Sore throat, swallowing problems.
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Inhibition of the enzyme causes free NE concentrations to rise. Likewise, dopamine catabolism is impaired, making more of it available for NE synthesis. Consequently, the amount of NE stored in granular vesicles will increase, and with it the amount of amine released per nerve impulse. In the CNS, inhibition of MAO affects neuronal storage not only of NE but also of dopamine and serotonin.
At dosages below those needed to treat malignancies, some cytostatics are also employed for immunosuppression, e. g. , azathioprine, methotrexate, and cyclophosphamide. The antiproliferative effect is not specific for lymphocytes and involves both T- and Bcells. Mycophenolate mofetil has a more specific effect on lymphocytes than on other cells.

 

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